Notwithstanding requirements for scientific/social value and risk/benefit proportionality in major research ethics policies, there are no widely accepted standards for these judgments in Phase 1 trials. This paper examines whether the principle of clinical equipoise can be used as a standard for assessing the ratio of risk to direct-benefit presented by drugs administered in one category of Phase 1 study—first-in-human trials involving patients. On the basis of the supporting evidence for, and architecture of, Phase 1 studies, the articles offers two (...) provisional conclusions: (1) the risks of drug administration in such trials cannot generally be justified on therapeutic grounds but by appeal to the social value of the research; and (2) a framework for adjudicating the ratio of risk/social-value must be developed. (shrink)

Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales. Information is stored in sequences, epigenetic modifications, and rapidly changing nucleoprotein complexes. Because DNA must operate through complexes formed with other molecules in the cell, genome functions are inherently interactive and involve two-way communication with various cellular compartments. Both coding sequences and repetitive sequences contribute to the hierarchical systemic organization of the genome. By virtue of nucleoprotein complexes, (...) epigenetic modifications, and natural genetic engineering activities, the genome can serve as a read-write storage system. An interactive informatic conceptualization of the genome allows us to understand the functional importance of DNA that does not code for protein or RNA structure, clarifies the essential multidirectional and systemic nature of genomic information transfer, and emphasizes the need to investigate how cellular computation operates in reproduction and evolution. (shrink)

As scientists target communities for research into the etiology, especially the genetic determinants of common diseases, there have been calls for the protection of communities. This paper identifies the distinct characteristics of aboriginal communities and their implications for research in these communities. It also contends that the framework in the Belmont Report is inadequate in this context and suggests a fourth principle of respect for communities. To explore how such a principle might be specified and operationalized, it reviews existing guidelines (...) for protecting aboriginal communities and points out problems with these guidelines and areas for further work. (shrink)

Wind turbines generate low-frequency sounds that affect the ear. The ear is superficially similar to a microphone, converting mechanical sound waves into electrical signals, but does this by complex physiologic processes. Serious misconceptions about low-frequency sound and the ear have resulted from a failure to consider in detail how the ear works. Although the cells that provide hearing are insensitive to infrasound, other sensory cells in the ear are much more sensitive, which can be demonstrated by electrical recordings. Responses to (...) infrasound reach the brain through pathways that do not involve conscious hearing but instead may produce sensations of fullness, pressure or tinnitus, or have no sensation. Activation of subconscious pathways by infrasound could disturb sleep. Based on our current knowledge of how the ear works, it is quite possible that low-frequency sounds at the levels generated by wind turbines could affect those living nearby. (shrink)

This article argues that we can and should recognize the mind dependence, epistemic dependence, and social dependence of theories of mind-independent reality, as opposed to Rorty, who thinks not even a constructivist theory of mind-independent reality can be had. It accuses Rorty of creating an equivocation or "dualism of scheme and content" between causation and justification based on various "Davidsonian" irrelevancies, not to be confused with the actual Davidson. These include the 'principle of charity', the attack against conceptual schemes, the (...) linguistification of social practice, intersubjectivism, and causal naturalism. It follows that realists and constructivists need neither follow Rorty's mischaracterizations nor succumb to his internal paradoxes. (shrink)

Approaches to the analysis of theory choice in science studies often focus either on objective criteria or subjective values for evaluating theories or on critical experiments for testing theories. In the present article a historical case study in the biomedical sciences is reconstructed, in which experimentation was performed to choose between two competing theories of blood coagulation. Analysis of this case study reveals that experimentation exhibits a particular structure, composed of design, execution, and results, and specific characteristics, consisting of controllability, (...) reproducibility, plasticity, and fecundity. Although this structure and these characteristics are not used to replace objective criteria or subjective values of theory evaluation or to define critical experiments, they are instrumental for analyzing and understanding theory choice. (shrink)

This paper provides an answer to this question: is the Christian of today rationally justified in using the views expressed in the Bible as a (or the) standard for what she should accept for her own beliefs and practices. I argue against trying to answer this question on thebasis of some alleged character of the biblical writings (e.g., their inerrancy or inspiredness). Such a thesis would itself have to be rationally justified, as would the interpretations and applications of biblical writings (...) made by a Christian of today who held the thesis. Instead she should seek to understand how the writers’ faith was expressed in their views and use that understanding to guide her as she constructs (or adopts) a set of beliefs by which to express her faith today. I argue that using the Bible in this way and the conclusions reached in doing so are rationally justified. (shrink)

In Foundationalism, Coherentism, and the Levels Gambit, David Shatz argued that foundationalists must countenance a circular mediate justification of perceptual beliefs which the foundationalist holds are already immediately justified. Because the circularity of coherentist accounts of the justification of beliefs is a major basis of foundationalist criticism of coherentism, Shatz's claim is a serious challenge to foundationalism. In this paper, using a moderate foundationalism with a reliabilist conception of justification, I give an account of immediately and mediately justified beliefs which (...) shows that such a foundationalism need not accept such a circular justification (and in crucial cases cannot do so) and that Shatz's claim is therefore incorrect. (shrink)

Why do bad things happen, even to good people? If there is a God, why aren't God's existence and God's will for humans more apparent? And if God really does miracles for some people, why not for others? This book examines these three problems of evil - suffering, divine hiddenness, and unfairness if miracles happen as believers claim - to explore how different ideas of God's power relate to the problem of evil.

I delineate four problems of evil encountered by Christian traditional theists (those who believe that God is all good, all knowing, and all powerful), and I present reasons for thinking that they have no good responses to these problems. Then I delineate important features of process metaphysics and discuss how this metaphysics solves the problems of evil. As conceived by process theists, God is all‐good and all‐knowing and has the greatest power any one being could have, but is not all‐powerful. (...) This God is related to the universe in such a way that the features of the world that generate the problems of evil are features to be expected rather than anomalies that require explanation, as they are for traditional theists. I also point out other features of the world that are anomalies for Christian traditional theists, but entirely to be expected by process theists. (shrink)

In his adoption of the Maimonidean guidelines for extreme humility, the king acts as the supreme existential model for imitatio dei. Imperial governance, when filtered through the prism of Maimonidean humility, results in a regime that most closely resembles a divine one. Using those who occupy the very bottom of the social and political hierarchy (slaves and orphans) as models, the king projects his own sense of "lowliness" to the people. The king thereby promotes their sense of autonomy, and inhibits (...) any anthropocentrism that would be fostered if he were to be viewed as an autocrat. His administration of the royal office is limited by the ethical and philosophical dictates of humility, thereby offering a window into the distinction between its common (anivut) and extreme (shefal ruah) manifestations. Maimonides does in fact define the parameters of this extraordinary humility, but he chooses to do so within the context of a distinct and concrete personality--that of the king. (shrink)

Michael Ruse‘s Darwinian metaethics has come under just criticism from Peter Woolcock (1993). But with modification it remains defensible. Ruse (1986) holds that people ordinarily have a false belief that there are objective moral obligations. He argues that the evolutionary story should be taken as an error theory, i.e., as a theory which explains the belief that there are obligations as arising from non-rational causes, rather than from inference or evidential reasons. Woolcock quite rightly objects that this position entails moral (...) nihilism. However, I argue here that people generally have justified true beliefs about which acts promote their most coherent set of moral values, and hence, by definition, about which acts are right. What the evolutionary story explains is the existence of these values, but it is not an error theory for moral beliefs. Ordinary beliefs correspond to real moral properties, though these are not objective or absolute properties independent of anyone‘s subjective states. On its best footing, therefore, a Darwinian metaethics of the type Ruse offers is not an error theory and does not entail moral nihilism. (shrink)